Abstract
H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.
Keywords: endometrium, endometrial cancer, RNA
How to Cite:
Devor, E. J., DeMik, J. N., Schickling, B. M., Goodheart, M. J. & Leslie, K. K., (2011) “H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.”, Proceedings in Obstetrics and Gynecology 2(1), 1–1. doi: https://doi.org/10.17077/2154-4751.1101
Rights: Copyright © Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie, 2011.
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