Abstract

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

Authors: Eric J Devor (University of Iowa) , Jill N. DeMik (University of Iowa) , Brandon M. Schickling (University of Iowa) , Michael J. Goodheart (University of Iowa) , Kimberly K. Leslie (University of Iowa)

  • H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

    Abstract

    H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

    Authors: , , , ,

Abstract

H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.

Keywords: endometrium, endometrial cancer, RNA

How to Cite:

Devor, E. J. & DeMik, J. N. & Schickling, B. M. & Goodheart, M. J. & Leslie, K. K., (2011) “H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.”, Proceedings in Obstetrics and Gynecology 2(1), 1-1. doi: https://doi.org/10.17077/2154-4751.1101

Rights: Copyright © Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie, 2011.

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Published on
28 Jul 2011
Peer Reviewed
License
CC BY 3.0