Abstract

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

Authors: Eric J Devor (University of Iowa) , Jill N. DeMik (University of Iowa) , Brandon M. Schickling (University of Iowa) , Michael J. Goodheart (University of Iowa) , Kimberly K. Leslie (University of Iowa)

Abstract

H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.

Keywords: endometrium, endometrial cancer, RNA

How to Cite: Devor, E. J. , DeMik, J. N. , Schickling, B. M. , Goodheart, M. J. & Leslie, K. K. (2011) “H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.”, Proceedings in Obstetrics and Gynecology. 2(1). doi: https://doi.org/10.17077/2154-4751.1101