Abstract

Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors

Authors: Aine Clements (University of Iowa) , David Engle (University of Iowa) , Dawne Shelton (University of Iowa) , Traci Neff (University of Iowa) , Soo Park (University of Iowa) , David Bender (University of Iowa) , Amina Ahmed (University of Iowa) , Koen De Geest (University of Iowa) , Anna Button (University of Iowa) , John F. Engelhardt (University of Iowa) , Michael Goodheart

  • Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors

    Abstract

    Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors

    Authors: , , , , , , , , , ,

Abstract

Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.

Keywords: LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer

How to Cite:

Clements, A. & Engle, D. & Shelton, D. & Neff, T. & Park, S. & Bender, D. & Ahmed, A. & De Geest, K. & Button, A. & Engelhardt, J. F. & Goodheart, M., (2011) “Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors”, Proceedings in Obstetrics and Gynecology 2(1), 1-2. doi: https://doi.org/10.17077/2154-4751.1106

Rights: Copyright © Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, and Michael J. Goodheart, 2011.

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Published on
28 Jul 2011
Peer Reviewed
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CC BY 3.0