Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.
Keywords: LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer
How to Cite:
Clements, A. & Engle, D. & Shelton, D. & Neff, T. & Park, S. & Bender, D. & Ahmed, A. & De Geest, K. & Button, A. & Engelhardt, J. F. & Goodheart, M., (2011) “Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors”, Proceedings in Obstetrics and Gynecology 2(1), 1-2. doi: https://doi.org/10.17077/2154-4751.1106
Rights: Copyright © Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, and Michael J. Goodheart, 2011.