Abstract

Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors

Authors: Aine Clements (University of Iowa) , David Engle (University of Iowa) , Dawne Shelton (University of Iowa) , Traci Neff (University of Iowa) , Soo Park (University of Iowa) , David Bender (University of Iowa) , Amina Ahmed (University of Iowa) , Koen De Geest (University of Iowa) , Anna Button (University of Iowa) , John F. Engelhardt (University of Iowa) , Michael Goodheart

Abstract

Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.

Keywords: LEF-1, ovarian cancer, fallopian tube cancer, peritoneal cancer

How to Cite: Clements, A. , Engle, D. , Shelton, D. , Neff, T. , Park, S. , Bender, D. , Ahmed, A. , De Geest, K. , Button, A. , Engelhardt, J. F. & Goodheart, M. (2011) “Lymphoid Enhancing Factor 1 (Lef-1) overexpression in epithelial ovarian, fallopian tube and peritoneal cancer and associations with clinical factors”, Proceedings in Obstetrics and Gynecology. 2(1). doi: https://doi.org/10.17077/2154-4751.1106