Abstract

Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia

Authors: Donna A. Santillan orcid logo (University of Iowa, Iowa City, Iowa) , Sabrina M. Scroggins (University of Iowa, Iowa City, Iowa) , Alyssa T. Ray (University of Iowa, Iowa City, Iowa) , Shao Y. Zhang (University of Iowa, Iowa City, Iowa) , Curt D. Sigmund (University of Iowa, Iowa City, Iowa) , Gary L. Pierce (University of Iowa, Iowa City, Iowa) , Justin L. Grobe (University of Iowa, Iowa City, Iowa) , Mark K. Santillan (University of Iowa, Iowa City, Iowa)

  • Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia

    Abstract

    Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia

    Authors: , , , , , , ,

Abstract

We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also assessed urine osmolality to further probe renal function.

Keywords: Osmolality, copeptin, arginine vasopressin, preeclampsia

How to Cite:

Santillan, D. A. & Scroggins, S. M. & Ray, A. T. & Zhang, S. Y. & Sigmund, C. D. & Pierce, G. L. & Grobe, J. L. & Santillan, M. K., (2018) “Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia”, Proceedings in Obstetrics and Gynecology 8(3), 1-2. doi: https://doi.org/10.17077/2154-4751.1436

Rights: Copyright © The authors, 2018.

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Published on
01 Dec 2018
Peer Reviewed
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CC BY 4.0