Abstract

First trimester elevation in circulating endothelin-1 and arterial stiffness are predictive of late pregnancy preeclampsia

Authors: Alexandria M. Betz (University of Iowa, Iowa City, Iowa) , Gary L. Pierce (University of Iowa, Iowa City, Iowa) , Donna A. Santillan orcid logo (University of Iowa, Iowa City, Iowa) , Eric J Devor (University of Iowa, Iowa City, Iowa) , Sabrina M. Scroggins (University of Iowa, Iowa City, Iowa) , Debra S. Brandt (University of Iowa, Iowa City, Iowa) , Amy K. Stroud (University of Iowa, Iowa City, Iowa) , Kellie M. Thomas (University of Iowa, Iowa City, Iowa) , Seth W. Holwerda (University of Iowa, Iowa City, Iowa) , Allison O’Deen (University of Iowa, Iowa City, Iowa) , Lyndsey E. DuBose (University of Iowa, Iowa City, Iowa) , Justin L. Grobe (University of Iowa, Iowa City, Iowa) , Curt D. Sigmund (University of Iowa, Iowa City, Iowa) , Mark K. Santillan (University of Iowa, Iowa City, Iowa)

  • First trimester elevation in circulating endothelin-1 and arterial stiffness are predictive of late pregnancy preeclampsia

    Abstract

    First trimester elevation in circulating endothelin-1 and arterial stiffness are predictive of late pregnancy preeclampsia

    Authors: , , , , , , , , , , , , ,

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Abstract

Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE; and 3) placental ET-1 is increased in PE. To address these questions, we performed a nested case-control study in women at risk for PE

Keywords: ET-1, endothelin-1, arterial stiffness, preeclampsia

How to Cite:

Betz, A. M. & Pierce, G. L. & Santillan, D. A. & Devor, E. J. & Scroggins, S. M. & Brandt, D. S. & Stroud, A. K. & Thomas, K. M. & Holwerda, S. W. & O’Deen, A. & DuBose, L. E. & Grobe, J. L. & Sigmund, C. D. & Santillan, M. K., (2018) “First trimester elevation in circulating endothelin-1 and arterial stiffness are predictive of late pregnancy preeclampsia”, Proceedings in Obstetrics and Gynecology 8(3), 1–2. doi: https://doi.org/10.17077/2154-4751.1431

Rights: Copyright © The authors, 2018.

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Published on
01 Dec 2018
Peer Reviewed
License
CC BY 4.0