Article

Toward a microRNA signature of endometrial cancer

Authors: Eric J. Devor (University of Iowa) , Michael J. Goodheart (University of Iowa) , Kimberly K. Leslie (University of Iowa)

  • Toward a microRNA signature of endometrial cancer

    Article

    Toward a microRNA signature of endometrial cancer

    Authors: , ,

Abstract

A simple meta-analysis of eight microRNA (miRNA) expression surveys of endometrial cancers reveals a panel of sixteen miRNAs that are significantly over-expressed (n = 15) or under-expressed (n = 1) in at least three surveys. Examination of these miRNAs indicates that they target mRNAs involved in a number of basic cellular processes including the crucial epithelial to mesenchymal transition (EMT) and hypoxia response. The central role played by these miRNAs is reinforced by the demonstration that they are all among the most ancient of all animal miRNAs. This suggests that they are members of a core set of miRNAs dysregulated as part of the carcinogenic cellular reprogramming process.

Keywords: microRNA, endometrial cancer

How to Cite:

Devor, E. J. & Goodheart, M. J. & Leslie, K. K., (2011) “Toward a microRNA signature of endometrial cancer”, Proceedings in Obstetrics and Gynecology 2(1), 1-7. doi: https://doi.org/10.17077/2154-4751.1104

Rights: Copyright © Eric J. Devor, Michael J. Goodheart, and Kimberly K. Leslie, 2011.

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Published on
28 Jul 2011
Peer Reviewed
License
CC BY 3.0