Conference Proceeding

Glaucoma Detection by Learning from Multiple Informatics Domains

Authors
  • Yanwu Xu (Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore)
  • Lixin Duan (Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore)
  • Damon Wing Kee Wong (Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore)
  • Tien Yin Wong (National University of Singapore)
  • Jiang Liu (Institute for Infocomm Research, Agency for Science, Technology and Research, Singapore)

Abstract

We present a comprehensive and fully automatic glaucoma detection approach that uses machine learning techniques over multiple informatics domains, consisting of personal profile data, genetic data, and retinal image data. This approach, referred to as MKLclm, enriches the feature set of the multiple kernel learning (MKL) framework through the incorporation of classemes, which represent the outputs of multiple class-specific classifiers trained from the data of each informatics domain. We validate our MKLclm framework on a population- based dataset consisting of 2258 subjects, achieving an AUC of 94.9% ± 1.7% and a specificity of 88.5% ± 2.7% at 85% sensitivity, which is significantly better than the current clinical standard of care which uses intraocular pressure (IOP) for glaucoma detection. The experiments also demonstrate that MKLclm outperforms the standard SVM method using data from individual domains, as well as the traditional MKL method, showing that this deeper integration of data from different informatics domains can lead to significant gains in holistic glaucoma diagnosis and screening.

How to Cite:

Xu, Y. & Duan, L. & Wong, D. W. & Wong, T. Y. & Liu, J., (2015) “Glaucoma Detection by Learning from Multiple Informatics Domains”, Proceedings of the Ophthalmic Medical Image Analysis International Workshop 2(2015), 17-24. doi: https://doi.org/10.17077/omia.1022

Rights: Copyright © 2015 Yanwu Xu, Lixin Duan, Damon Wing Kee Wong, Tien Yin Wong, and Jiang Liu

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Published on
09 Oct 2015
Peer Reviewed