Evaluation of the VNTR region in the IDO promoter in women with preeclampsia
Authors:
Erica Hofland
(University of Iowa, Iowa City, IA)
,
Eric J Devor
(University of Iowa, Iowa City, IA)
,
Stephen K. Hunter
(University of Iowa, Iowa City, IA)
,
Mark K. Santillan
(University of Iowa, Iowa City, IA)
,
Donna A. Santillan
(University of Iowa, Iowa City, IA)
Abstract
Indoleamine 2,3 – dioxygenase (IDO) is an enzyme that aids in immunosuppression and tolerance. Previous studies have shown decreased IDO activity in pregnancies affected by preeclampsia, but the mechanism for this altered activity is unknown. Our study was designed to analyze the promoter region of IDO in preeclamptic and control women and identify the frequency of a VNTR genotype that has been shown to be significantly correlated with tryptophan levels in women; a surrogate marker for IDO activity.
Keywords: preeclampsia, Indoleamine 2, 3–dioxygenase, pregnancy
How to Cite:
Hofland, E. & Devor, E. J. & Hunter, S. K. & Santillan, M. K. & Santillan, D. A., (2013) “Evaluation of the VNTR region in the IDO promoter in women with preeclampsia”, Proceedings in Obstetrics and Gynecology 3(3), 1–2. doi: https://doi.org/10.17077/2154-4751.1236
Rights: Copyright © Erica Hofland, Eric J. Devor, Stephen K. Hunter, Mark K. Santillan, Donna A. Santillan, 2013.
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