Impact of vasopressin receptors on regulation of immune response in preeclampsia
Authors:
Kathryn Huber-Keener
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
,
Sabrina M Scroggins
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
,
Donna A. Santillan
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
,
Daffney Gomendoza
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
,
Lindsay Krotz,
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
,
Jeremy Sandgren,
(Department of Pharmacology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242)
,
Justin L Grobe
(Department of Pharmacology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242)
,
Mark K. Santillan
(Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
Abstract
Preeclampsia is a common disorder of pregnancy resulting in increased blood pressure and end organ effects. The pathogenesis of preeclampsia is multi-factorial. Arginine vasopressin (AVP) is increased in preeclampsia, and the chronic infusion of AVP throughout gestation has previously been shown to be sufficient to produce a phenotype of preeclampsia in C57BL/6J mice representative of some of the cardiovascular and renal events seen in humans. Alterations in T-helper cell populations and their effector cytokines are also known to occur in preeclampsia. Therefore, we proposed that the increased secretion of AVP may be responsible for the immune changes that occur in preeclampsia. We also hypothesized that known pharmacological AVP antagonist, vaptans, may be able to reverse the effects of AVP infusion.
Keywords: Preeclampsia, vasopressin, immune, Arginine vasopressin, AVP
How to Cite:
Huber-Keener, K. & Scroggins, S. M. & Santillan, D. A. & Gomendoza, D. & Krotz,, L. & Sandgren,, J. & Grobe, J. L. & Santillan, M. K., (2018) “Impact of vasopressin receptors on regulation of immune response in preeclampsia”, Proceedings in Obstetrics and Gynecology 8(1), 1–2. doi: https://doi.org/10.17077/2154-4751.1388
Rights: Copyright © The authors, 2018.
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