Review Article

Wnt/ß-catenin/Lef-1 signaling in the uterus and its implications in uterine gland formation and cancer development

Authors: Dawne N. Shelton (University of Iowa) , Michael J. Goodheart (University of Iowa)

  • Wnt/ß-catenin/Lef-1 signaling in the uterus and its implications in uterine gland formation and cancer development

    Review Article

    Wnt/ß-catenin/Lef-1 signaling in the uterus and its implications in uterine gland formation and cancer development

    Authors: ,

Abstract

Wnt/b-catenin signaling appears to be important in a multitude of cancers. This review article details current knowledge of the Wnt/b-catenin/Lef1 pathway in generalized gland regulation and formation in addition to endometrial cancer. Wnt signaling is critical for the development of the female urogenital system, in particular mullerian duct formation. Dysregulation of this signaling pathway at multiple nodes has been observed in numerous tumor types, including endometrial cancer. In particular, nuclear accumulation of b-catenin correlates with tumor severity. As such, therapeutic modulation of Wnt signaling represents an emerging avenue for the treatment of cancers that rely on this pathway.

Keywords: beta Catenin, cancer, Lymphoid Enhancer-Binding Factor 1, neoplasms, uterus, Wnt proteins

How to Cite:

Shelton, D. N. & Goodheart, M. J., (2011) “Wnt/ß-catenin/Lef-1 signaling in the uterus and its implications in uterine gland formation and cancer development”, Proceedings in Obstetrics and Gynecology 2(1), 1-11. doi: https://doi.org/10.17077/2154-4751.1113

Rights: Copyright © Dawne N. Shelton, Michael J. Goodheart, 2011.

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Published on
28 Jul 2011
Peer Reviewed
License
CC BY 3.0