Abstract

The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer

Authors: Xiangbing Meng (University of Iowa) , Laura L. Laidler (University of New Mexico) , Lina Albitar (University of New Mexico) , Anna M. Holmes (University of New Mexico) , Donghai Dai (University of Iowa) , Thomas E. Buekers (University of Iowa) , David P. Bender (University of Iowa) , Kimberly K. Leslie (University of Iowa)

  • The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer

    Abstract

    The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer

    Authors: , , , , , , ,

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Abstract

Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.

Keywords: Paclitaxel, Gefitinib, endometrial cancer, mitotic catastrophe, p38, p53

How to Cite:

Meng, X. & Laidler, L. L. & Albitar, L. & Holmes, A. M. & Dai, D. & Buekers, T. E. & Bender, D. P. & Leslie, K. K., (2011) “The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer”, Proceedings in Obstetrics and Gynecology 2(1), 1–2. doi: https://doi.org/10.17077/2154-4751.1099

Rights: Copyright © Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, Kimberly K. Leslie, 2011.

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Published on
28 Jul 2011
Peer Reviewed
License
CC BY 3.0