Abstract

The relationship between vascularity, p53 gene mutations and distant metastatic disease in epithelial ovarian carcinoma

Authors: Janna Girardi (University of Iowa) , Megan Samuelson (University of Iowa) , Anna Button (University of Iowa) , Koen De Geest (University of Iowa) , David P. Bender (University of Iowa) , Amina Ahmed (University of Iowa) , Michael Goodheart

Abstract

Mutations of the p53 tumor suppressor gene are associated with large differences (>7 vessels/HPF) in Microvessel density (MVD) counts between primary and metastatic tumor sites in patients with epithelial ovarian cancer. These data are consistent with models demonstrating p53 mutation functions directly to influence angiogenesis. This information supports continued therapy and research involving angiogenesis inhibitors in patients with ovarian cancer, especially in the setting of increased differences in MVD between primary and metastatic sites.

Keywords: vascularity, P53, gene mutations, metastatic disease, epithelial, ovarian cancer

How to Cite: Girardi, J. , Samuelson, M. , Button, A. , De Geest, K. , Bender, D. P. , Ahmed, A. & Goodheart, M. (2011) “The relationship between vascularity, p53 gene mutations and distant metastatic disease in epithelial ovarian carcinoma”, Proceedings in Obstetrics and Gynecology. 2(1). doi: https://doi.org/10.17077/2154-4751.1109