Extended Abstract
Authors: Eric M Tyler (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Donna A. Santillan (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Sabrina M. Scroggins (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Eric J. Devor (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Wendy S. Hamilton (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Stephen K. Hunter (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242) , Mark K. Santillan (Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242)
For a successful pregnancy to occur, foreign genetic material such as the allogeneic fetus must be tolerated within the maternal host. Indoleamine 2,3-dioxygenase (IDO) is an enzyme induced by pro-inflammatory cytokines that has been shown to be key to this process. Obesity as a pro-inflammatory state is associated with poor obstetric outcomes. The primary objective of this study is to investigate the relationship between obesity and IDO activity.
Keywords: Preeclampsia, obesity in pregnancy, immunology of pregnancy, fetal tolerance
How to Cite: Tyler, E. M. , Santillan, D. A. , Scroggins, S. M. , Devor, E. J. , Hamilton, W. S. , Hunter, S. K. & Santillan, M. K. (2015) “The relationship between obesity, pregnancy, and levels of indoleamine 2,3-dioxygenase”, Proceedings in Obstetrics and Gynecology. 5(3). doi: https://doi.org/10.17077/2154-4751.1301